It sounds like a good idea to me. I'm starting to experiment with the idea a bit, too.
Using different profiles does allow you to differentiate them in plan (with a different fill, for example) so that different wall thicknesses have different appearances. It would also make it easier to keep track of different wall types if you do automated takeoffs or schedules based on them.
Keppers Design Architecture
AC 23, 24, 25, 26
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