No problem at all. See my signature. Renderings may be a bit slow, but not slower than AC9. With Artlantis it works fine, though. But you should max the RAM to what the machine handles, if possible. And a better graphics card (I've got an ATI 9000 Pro with 128 MB VRAM) makes the Open GL engine faster.
AC4.1-AC26SWE; MacOS13.5.1; MP5,1+MBP16,1